Pesticide exposure tied to asthma in farmers

Last Updated: 2007-09-17 10:38:16 -0400 (Reuters Health)
By Anthony J. Brown, MD

NEW YORK (Reuters Health) - Exposure to several commonly used pesticides appears to increase the risk of asthma, US researchers report.

This finding stems from a study of nearly 20,000 farmers, which was presented Sunday at the European Respiratory Society Annual Congress in Stockholm.

Pesticide exposure is a "potential risk factor for asthma and respiratory symptoms among farmers," lead author Dr. Jane A. Hoppin, from the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina, told Reuters Health.

"Because grains and animals are more common exposures in agricultural settings, pesticides may be overlooked," Hoppin warned, adding: "Better education and training of farmers and pesticide handlers may help to reduce asthma risk."

Of the 19,704 farmers included in the study, 127 had self-reported (doctor diagnosed) allergic asthma and 314 had non-allergic asthma.

The main finding was that a history of high pesticide exposure was associated with a doubling of asthma risk, Hoppin noted. The link remained statistically significant after adjusting for a variety of potentially confounding factors including age, smoking, body weight, and state of residence.

Overall, 16 of the pesticides studied were associated with asthma: 12 with the allergic variety of asthma and 4 with the non-allergic type. Coumaphos, EPTC, lindane, parathion, heptachlor, and 2,4,5-TP were most strongly linked to allergic asthma. For non-allergic asthma, DDT, malathion, and phorate had the strongest effect.

"This is the first study with sufficient power to evaluate individual pesticides and adult asthma among individuals who routinely apply pesticides," Hoppin noted. Moreover, this is the only study to date to do this for allergic and non-allergic asthma separately, the researcher said.




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